Structured exercise reduces NfL levels

Early findings indicate that structured exercise programmes could significantly lower blood levels of neurofilament light chain (NfL) in people living with multiple sclerosis (MS). NfL is a protein found in neurons and serves as a biomarker for tracking and predicting disease activity and progression in neurological conditions. The research, led by Seraj Makkawi and his team, reviewed seven previous studies and found that activities such as outdoor Pilates and home-based exercise notably reduced NfL levels. In contrast, no significant changes were observed in a control group that did not participate in these activities.

Further analysis suggested that just eight weeks of exercise could lead to a meaningful reduction in NfL levels. However, Dr. Makkawi and his colleagues cautioned that while these results are promising, further research with more rigorous study designs is necessary to confirm the potential benefits of exercise for managing MS.